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Uncontrolled consumption of medical plants may lead controversial result over the patients who are receiving radiotherapy or chemotherapy for cancer treatment. Especially, flavonoid free radical scavenger including chemical and plants may not be innocent as much as thought. Free radical scavenger antioxidant extracts uses for commonly for two aims; the prevention of cancer and therapy of cancer.
In the light of recent developments the impact of antioxidant usage on cancer treatment and prevention is shortly reviewed in this article
Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/ glutathione couple. Free Radic Biol Med, 2001: 30; 1191-212.
Chamond RR, Anon JC, Guerra P, et al. Apoptosis and disease. Alergol Immunol Clin, 1999: 14; 367-74.
Gerhauser C. Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med, 2008: 74; 1608-24.
Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett, 2008: 269; 315-25.
Siu D. A new way of targeting to treat coronary artery disease. J Cardiovasc Med (Hagerstown), 2010: 11; 1-6.
Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. Sci Transl Med. 2015 Oct 7;7(308):308
Davison CA1, Durbin SM, Thau MR, Zellmer VR, Chapman SE, Diener J, Wathen C, Leevy WM, Schafer ZT. Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix. Cancer Res. 2013 Jun 15;73 (12):3704-15.
Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009;301(1):52-62.
Fortmann SP, Burda BU, Senger CA, et al. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the U.S. Preventive Services Task Force. Annals of Internal Medicine 2013
Hejazi J, Rastmanesh R, Taleban FA, Molana SH, Hejazi E, Ehtejab G, Hara N. Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study. Nutr Cancer. 2016 Jan 15:1-9. [Epub ahead of print]
Peh HY1, Tan WS1, Liao W1, Wong WS2. Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol. Pharmacol Ther. 2015 Dec 17. pii: S0163-7258(15)00229-6. doi: 10.1016/j.pharmthera.2015.12.003. [Epub ahead of print]