Turmeric Curcuminoid Polyphenolics as Antioxidant and Anticarcinogenic Agents
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Published:
Dec 14, 2015
Keywords:
Turmeric Curcuma longa Antioxidant Anticarcinogen
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Abstract
In this review content, it has been described the botanical and the chemical properties of turmeric (Curcuma longa), and its curcuminoid polyphenolic structures and antioxidant and anticarcinogenic influences on various cell proliferation and apoptosis. Besides it was emphasized the innovative anticarcinogen complex as boron-curcumin, and the safety evaluation with turmeric curcumin and the dose and toxicity in consuming for animals and human
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How to Cite
Tokusoglu, O. ., Simsek, A. ., Parvizi, M., & Eymen, D. (2015). Turmeric Curcuminoid Polyphenolics as Antioxidant and Anticarcinogenic Agents. Natural Science and Discovery, 1(3), 56–61. https://doi.org/10.20863/nsd.v1i3.14
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Review Article
References
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Anonymous 2015. Curcuma longa. Alternative Medicine Review Monographs. 119-125.
Ruby A.J., Kuttan G., Dinesh B., Rajasekharan K.N., Kuttan R. 1995. Antitumor and antioxidant activity of natural curcuminoids. Cancer Lett., 94, 79-83
Basu A., Suresh Kumar G. 2014. Interaction of the dietary pigment curcumin with hemoglobin: energetics of the complexation. Vol 5, Food Funct. 1949-1955.
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research. 23, 363-398.
Ammon H.P.,Wahl M.A. 1991.Pharmacology of Curcuma longa. Planta Med. 1991,57,1–7.
Chan, M.M., Adapala, N.S., Fong, D. 2005. Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania. Parasitol Res. 96, 49-56.
Sreejayan S., Rao M.N. 1997.Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49, 105-107.
Brouet I.; Ohshima H. 1995. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 206, 533-540. 5.
Dikshit M., Rastogi L., Shukla R., Srimal R.C. 1995. Prevention of ischaemia-induced biochemical changes by curcumin & quinidine in the cat heart. Indian J. Med. Res. 101, 31-35.
Kiso Y., Suzuki Y., Watanabe N., Oshima Y., Hikino H. 1983. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. 49, 185-187.
Vishwanatha Swamy A., Gulliaya S., Thippeswamy A., Koti B.C., Manjula D.V. 2012. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol. 44(1): 73–77.
Srivastava R. Dikshit M., Srimal R.C., Dhawan B.N. 1985. Thrombosis Research, 40(3):413-7
Zahidah A.F., Faizah O., Nur Aqilah K., Tatyanna K. 2012. Curcumin as an Anti-Arthritic Agent in Collagen-Induced Arthritic Sprague-Dawley Rats. Sains Malaysiana, 41(5), 591–595
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Review. Anticancer Research, 23, 363-398.
López-Lázaro M. 2008.Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res. 52(1), 103-27.
Sharma O.P. 1976. Antioxidant activity of curcumin and related compounds. Biochem.Pharmacol., 25, 1811-1812.
Wright J.S. 2002. Predicting the antioxidant activity of curcumin and curcuminoids. J.Mol Struct., 591, 207-217.
Anand P., Thomas S.G., Kunnumakkara A.B., Sundaram C., Harikumar K.B., Sung B., Tharakan S.T., Misra K., Priyadarsini I.K., Rajasekharan K.N., Aggarwal B.B. 2008. Biological activities of curcumin and its analogues (congeners) made by man and mother natüre. Biochemical Pharmacology. 76, 1590-1611.
Priyardarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G. et.al.. 2003. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med. 35, 475-484.
Barclay L.R., Vinqvist M.r., Mukai K., Goto H., Hashimoto Y., Tokunaga A. et.al. 2000. On the antioxidant mechanism of curcumin: classical methods are needed to determine antioxidant mechanism and activity. Org.Lett. 2, 2841-2843.
Jovanovic S.V., Steenken S., Boone C.W., Simic M.G.. 1999. H-atom transfer is a preferred antioxidant mechanism of curcumin. J. Am.Chem. Soc., 121, 9677-9681.
Suzuki M., Nakamura T., Iyoki S., Fujiwara A., Watanabe Y., Mohri K. et.al. 2005. Elucidation of anti-allergenic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull, 28, 1438-1443.
Chen W.F., Deng S.I., Zhou B., Yang L., Liu Z.I. 2006. Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups. Free Radic Biol Med., 40, 526-535.
Labban L. 2014. Medicinal and pharmacological properties of Turmeric (Curcuma longa): A review. Int J Pharm Biomed Sci, 5(1):17-23.
Huang H.C., Jan T.R., Yeh S.F. 1992. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 221, 381-384.
Chen H, Zhang ZS, Zhang YL, Zhou DY. 1999. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 19, 3675-3680.
Martin-Cordero C., Lopez-Lazaro M., Galvez M., Ayuso M.J. 2003. Curcumin as a DNA topoisomerase II poison. J.Enzyme Inhib.Med.Chem., 18, 505-509.
Wanninger S., Lorenz V., Subhanb A., Edelmann F.T. 2015. Metal complexes of curcumin- synthetic strategies, structures and medicinal applications. Chem. Soc. Rev., 44, 4986-5002.
Ammon HPT, Wahl MA. 1991. Pharmacology of Curcuma longa. Planta Medica 57:1-7.
Bhavani Shankar T.N., Shantha N.V., Ramesh H.P., Murthy I.A.S., Murthy V.S. 1980. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. Indian J. Exp. Biol., 8, 73–75.
Sambaiah K., Ratankumar S., Kamanna V.S., Satyanarayana M.N., Rao M.V.L. 1982. Influence of turmeric and curcumin on growth, blood constituents and serum enzymes in rats. J. Food Sci. Technol., 19, 187-190.
Eigner D., Scholz D.1999. Ferula asa-foetida and Curcuma longa in traditional medicinal treatment and diet in Nepal. J. Ethnopharmacol., 67, 1–6.
Chainani-Wu, N. 2003. Safety and antiinflammatory activity of curcumin: a component of turmeric (Curcuma longa). J.Altern.Complement Med., 9, 161-168.
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res., 23, 363–398.
Anonymous 2015. Curcuma longa. Alternative Medicine Review Monographs. 119-125.
Ruby A.J., Kuttan G., Dinesh B., Rajasekharan K.N., Kuttan R. 1995. Antitumor and antioxidant activity of natural curcuminoids. Cancer Lett., 94, 79-83
Basu A., Suresh Kumar G. 2014. Interaction of the dietary pigment curcumin with hemoglobin: energetics of the complexation. Vol 5, Food Funct. 1949-1955.
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research. 23, 363-398.
Ammon H.P.,Wahl M.A. 1991.Pharmacology of Curcuma longa. Planta Med. 1991,57,1–7.
Chan, M.M., Adapala, N.S., Fong, D. 2005. Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania. Parasitol Res. 96, 49-56.
Sreejayan S., Rao M.N. 1997.Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49, 105-107.
Brouet I.; Ohshima H. 1995. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 206, 533-540. 5.
Dikshit M., Rastogi L., Shukla R., Srimal R.C. 1995. Prevention of ischaemia-induced biochemical changes by curcumin & quinidine in the cat heart. Indian J. Med. Res. 101, 31-35.
Kiso Y., Suzuki Y., Watanabe N., Oshima Y., Hikino H. 1983. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. 49, 185-187.
Vishwanatha Swamy A., Gulliaya S., Thippeswamy A., Koti B.C., Manjula D.V. 2012. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol. 44(1): 73–77.
Srivastava R. Dikshit M., Srimal R.C., Dhawan B.N. 1985. Thrombosis Research, 40(3):413-7
Zahidah A.F., Faizah O., Nur Aqilah K., Tatyanna K. 2012. Curcumin as an Anti-Arthritic Agent in Collagen-Induced Arthritic Sprague-Dawley Rats. Sains Malaysiana, 41(5), 591–595
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Review. Anticancer Research, 23, 363-398.
López-Lázaro M. 2008.Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res. 52(1), 103-27.
Sharma O.P. 1976. Antioxidant activity of curcumin and related compounds. Biochem.Pharmacol., 25, 1811-1812.
Wright J.S. 2002. Predicting the antioxidant activity of curcumin and curcuminoids. J.Mol Struct., 591, 207-217.
Anand P., Thomas S.G., Kunnumakkara A.B., Sundaram C., Harikumar K.B., Sung B., Tharakan S.T., Misra K., Priyadarsini I.K., Rajasekharan K.N., Aggarwal B.B. 2008. Biological activities of curcumin and its analogues (congeners) made by man and mother natüre. Biochemical Pharmacology. 76, 1590-1611.
Priyardarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G. et.al.. 2003. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med. 35, 475-484.
Barclay L.R., Vinqvist M.r., Mukai K., Goto H., Hashimoto Y., Tokunaga A. et.al. 2000. On the antioxidant mechanism of curcumin: classical methods are needed to determine antioxidant mechanism and activity. Org.Lett. 2, 2841-2843.
Jovanovic S.V., Steenken S., Boone C.W., Simic M.G.. 1999. H-atom transfer is a preferred antioxidant mechanism of curcumin. J. Am.Chem. Soc., 121, 9677-9681.
Suzuki M., Nakamura T., Iyoki S., Fujiwara A., Watanabe Y., Mohri K. et.al. 2005. Elucidation of anti-allergenic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull, 28, 1438-1443.
Chen W.F., Deng S.I., Zhou B., Yang L., Liu Z.I. 2006. Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups. Free Radic Biol Med., 40, 526-535.
Labban L. 2014. Medicinal and pharmacological properties of Turmeric (Curcuma longa): A review. Int J Pharm Biomed Sci, 5(1):17-23.
Huang H.C., Jan T.R., Yeh S.F. 1992. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 221, 381-384.
Chen H, Zhang ZS, Zhang YL, Zhou DY. 1999. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 19, 3675-3680.
Martin-Cordero C., Lopez-Lazaro M., Galvez M., Ayuso M.J. 2003. Curcumin as a DNA topoisomerase II poison. J.Enzyme Inhib.Med.Chem., 18, 505-509.
Wanninger S., Lorenz V., Subhanb A., Edelmann F.T. 2015. Metal complexes of curcumin- synthetic strategies, structures and medicinal applications. Chem. Soc. Rev., 44, 4986-5002.
Ammon HPT, Wahl MA. 1991. Pharmacology of Curcuma longa. Planta Medica 57:1-7.
Bhavani Shankar T.N., Shantha N.V., Ramesh H.P., Murthy I.A.S., Murthy V.S. 1980. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. Indian J. Exp. Biol., 8, 73–75.
Sambaiah K., Ratankumar S., Kamanna V.S., Satyanarayana M.N., Rao M.V.L. 1982. Influence of turmeric and curcumin on growth, blood constituents and serum enzymes in rats. J. Food Sci. Technol., 19, 187-190.
Eigner D., Scholz D.1999. Ferula asa-foetida and Curcuma longa in traditional medicinal treatment and diet in Nepal. J. Ethnopharmacol., 67, 1–6.
Chainani-Wu, N. 2003. Safety and antiinflammatory activity of curcumin: a component of turmeric (Curcuma longa). J.Altern.Complement Med., 9, 161-168.
Aggarwal B.B., Kumar A., Bharti A.C. 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res., 23, 363–398.